Semax Peptide (ACTH 4-10 Fragment): Research Overview
Semax (MEHFPGP), the synthetic ACTH(4-10) fragment: what preclinical research examines about BDNF and monoamine signalling in model systems.
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro, MEHFPGP) based on the ACTH(4-10) fragment, modified with a C-terminal Pro-Gly-Pro to improve stability. It is studied as a water-soluble research peptide.
Structure and identity
The Pro-Gly-Pro extension reduces enzymatic degradation relative to the native ACTH fragment. Semax is supplied as a lyophilised powder for laboratory reconstitution.
What the research literature examines
In-vitro and animal studies have investigated Semax in relation to BDNF expression and dopaminergic and serotonergic signalling in model systems. This work is exploratory. Vivera Labs makes no claims regarding effects in humans; the compound is supplied strictly for in-vitro laboratory research.
Why purity matters for this peptide
As with all neuropeptide research tools, assay validity depends on sequence fidelity. Each batch is independently HPLC-tested with a Certificate of Analysis available on request.
- Identity confirmed by mass spectrometry
- Purity quantified by HPLC
- Batch-specific documentation
- Cold-chain stored
The references at the end of this article name the peer-reviewed sources behind it.
Frequently Asked Questions
What is Semax?
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP), based on the ACTH(4-10) fragment and modified with a C-terminal Pro-Gly-Pro. It is supplied as a water-soluble research peptide in lyophilised powder form for laboratory reconstitution.
Why does Semax have a Pro-Gly-Pro extension?
The C-terminal Pro-Gly-Pro extension is added to improve stability. It reduces enzymatic degradation relative to the native ACTH fragment.
What has research on Semax examined?
In-vitro and animal studies have investigated Semax in relation to BDNF expression and dopaminergic and serotonergic signalling in model systems. This work is exploratory. Vivera Labs makes no claims regarding effects in humans; the compound is supplied strictly for in-vitro laboratory research.
How is Semax purity verified?
Assay validity depends on sequence fidelity, so each batch is independently HPLC-tested with a Certificate of Analysis available on request. Identity is confirmed by mass spectrometry, purity is quantified by HPLC, and material is batch-documented and cold-chain stored.
For in-vitro laboratory research use only. Not for human or veterinary use, consumption, or therapeutic application. No medical claims are made.