SS-31
Mitochondria-targeted peptide (Elamipretide). Cellular energy research.
Specification
- Catalogue ID: SP141
- Listed purity specification: 99.5%
- Formulation: Lyophilized
- Quantity: 50mg / Vial
- Price: £171.00
Mitochondrial bioenergetics · cardiolipin interaction research
SS-31 (elamipretide) is a mitochondria-targeting synthetic tetrapeptide: D-Arg-dimethyltyrosine-Lys-Phe-NH₂. The alternating cationic and aromatic amino acid architecture — characteristic of the Szeto-Schiller (SS) peptide family — confers high membrane permeability and selective accumulation within the inner mitochondrial membrane (IMM).
The compound has been extensively characterised in vitro for its binding to cardiolipin, the signature phospholipid of the IMM. This interaction stabilises cytochrome c association with the membrane, preserving electron-transport chain (ETC) architecture and reducing electron leak — a mechanism central to mitochondrial bioenergetics research.
In isolated mitochondria preparations, SS-31 has been studied for its effects on membrane potential (ΔΨm), ATP synthesis efficiency, and reactive oxygen species (ROS) generation under substrate-limited conditions, making it a widely used tool compound in mitochondrial-stress assay systems.
No physiological or therapeutic properties are claimed; supplied for in-vitro laboratory research use only.
Compound identity
- CAS number: 736992-21-5
- Molecular formula: C₃₂H₄₉N₉O₅
- Molecular weight: 639.80 Da
- Sequence: D-Arg-Dmt-Lys-Phe-NH₂
- Solubility: Soluble in water at ≥1 mg/mL
- Reconstitution: Add 1 mL bacteriostatic water per 5 mg; swirl gently
For in-vitro laboratory research use only. Not for human or veterinary use, consumption, or therapeutic application. No medical claims are made.